Guardian of the Nuclear Envelope: How the UBE3C Protein Protects Cells from Aging
The cell nucleus is like a tent held up by internal poles. These poles, the lamin proteins, wear out with age, and the tent sags. For a long time scientists could not figure out who exactly keeps the poles intact and why they hold up longer in some people than in others.
The answer turned up in the genes of long-lived people.