Why fasting rejuvenates muscles differently in men and women ✎ bioRxiv

Original: "Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation in Nothobranchius furzeri."
b42w:2602.90010 · the paper's page · 2026-02-11 · CC BY-NC-ND 4.0 · independent analysis · 1 min
A tiny fish has shown that male and female muscles age differently, and fasting repairs them in different ways.

In African ponds lives a fish that manages to grow old within a single summer. Scientists noticed that if you feed it every other day, it lives longer. But the most interesting part is how fasting affects muscles. In females, it restores the fast-twitch muscle fibers needed for sudden movements. In males, fat and sugar processing improves.

In old fish after fasting, muscles don't get bigger, but they swim faster than young ones. So it's not about muscle size, but about how they work.

This is like renovating a house: females fix the wiring, while males fix the heating. That's why the same diet can't help everyone equally. Doctors should consider a patient's sex when they recommend fasting to preserve strength in old age.

The killifish Nothobranchius furzeri lives in ephemeral pools in Mozambique and Zimbabwe that dry up within a few months. Its eggs can survive complete desiccation in diapause for a year or more. In the laboratory the fish live 4-6 months, making them the shortest-lived vertebrates bred in captivity.

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Not published on arXiv. Here are its page, the PDF and the formalization: you can check it yourself, not only read our account.