epigenetics

A forensic examiner arrives at a crime scene and lifts fingerprints. Epigenetic clocks work the same way: from chemical marks on DNA they determine how much a cell has aged. A tumor leaves its own "fingerprints," and almost always they point to decrepitude. The researchers took 5528 samples from the TCGA database, which holds DNA methylation data for eight cancer types.

A Greenland shark swims through cold water in its fourth century, and with every passing year its odds of dying do not rise but fall. This is not a miracle, but the result of an evolutionary trade-off that has so far eluded theory. An organism is like a family budget that cannot be spent twice: every unit of energy can go into reproduction, growth, or body repair.

Every morning, while their parents are still asleep, thousands of children wake up to the hum of a highway. That hum becomes the first sound of their lives, and the neighborhood where they were born becomes their first starting block. Some children begin on a level track, others on a track that tilts upward, and the pace of their biological clocks differs from the very first steps.

A drop of blood on filter paper preserves not only cells but also a record of what has been happening to the body over the past few months. That record is not in the genes but on them: the chemical marks cells attach to DNA change with food, stress, illness and age. Scientists have learned to read this archive tape to reconstruct a picture of health without repeated trips to the lab.

Blood stem cells are like spare keys to a house: they open the door to any room, but over time they wear down and start to stick. In an elderly person, such keys handle the locks worse, and the blood renews itself more slowly. Scientists have long been searching for a way to make a duplicate that stays new even after heavy use.