نوعان من الخلايا يتحركان بتناغم سريع

الملخص الأصلي

كما كتبه المؤلفون، بالإنجليزية arXiv:2607.09296

Chemotaxis underlies the collective migration of cell populations in developmental processes and immune responses. While the theoretical investigation of single-cell-type collective chemotaxis has received considerable attention, heterogeneous chemotaxis involving multiple interacting cell types remains poorly understood. Here, we generalise a model of heterogeneous self-generated chemotaxis and analyse the resulting collective migration patterns. We show that coupled migration between two cell types gives rise to \emph{propagating terraces} -- coupled travelling fronts moving at different speeds. While a sensor-only population leads the migrating collective, a slower mixed sensor-consumer population follows. Our analysis reveals that these fronts are coupled via the dynamics of the self-generated chemoattractant gradients. We derive analytical expressions for the migration speeds of the two fronts just in term of model parameters and experimentally measurable quantities. Our analytical results reveal that heterogeneity can enhance long-range migration via self-generated chemotaxis for sensor cells. While sensor cells can leverage benefit from mixing with consumer cells, the latter migrate more efficiently when mixing with cells of the same type. Together, our results provide a comprehensive theoretical framework for understanding heterogeneous self-generated chemotaxis.