Two Ways to Hear a Cell: How Sequencing Platforms Are Changing the Picture of Transcriptional Noise
Two different microphones are recording the same concert. One microphone stands by the stage and mostly picks up the loud sounds from the front row; the other hangs from the ceiling and hears the whole hall, but with the bass muffled. If you compare the recordings, you can figure out how much of the noise in them comes from the microphone and how much from the orchestra itself.