lifespan

Picture every blood test as a dot on a large map. Plot thousands of those dots and they won't scatter at random: they line up along two main roads. One road separates men from women, the other stretches from youth to old age. Follow these roads and you can see how a person grows up, lives and grows old.

In a psychologist's quiet office, a fourteen-year-old fills out a questionnaire about childhood. The scores climb, and on the MRI scans the amygdala climbs with them: a small node deep in the brain that teaches us to fear and to remember danger. In a rat held in a narrow tube for three hours a day, the same structure grows faster than in its calm counterparts.

Every one of us has wondered at least once how many years we'll live. In 1996, nearly two and a half thousand Japanese people over sixty answered that question in a national survey. Their answers became a kind of mirror reflecting hopes, fears, and habits of thought. Twenty-eight years later, researchers compared those forecasts with actual dates of death and found that the mirror was warped, but not useless.

A Greenland shark swims through cold water in its fourth century, and with every passing year its odds of dying do not rise but fall. This is not a miracle, but the result of an evolutionary trade-off that has so far eluded theory. An organism is like a family budget that cannot be spent twice: every unit of energy can go into reproduction, growth, or body repair.

The liver is an orchestra in which every cell plays its part from a shared score. Males and females have different scores: in males, the genes responsible for detoxifying foreign substances and steroid hormones sound louder, while in females, the genes for fat metabolism and bile acids do.