كيف تختار الخلايا شكل الجسم سريع

الملخص الأصلي

كما كتبه المؤلفون، بالإنجليزية arXiv:2603.07082

The emergence of nematic order on deformable closed surfaces plays a pivotal role in the morphogenesis of active biological matter, such as the regeneration of Hydra. In this work, we present a continuum model that couples the two-dimensional Landau-de Gennes order tensor, describing in-plane nematic ordering, with the mechanics of a mass-conserving, deformable spherical shell. By investigating the isotropic-to-nematic phase transition driven by a reduction in temperature, mimicking the natural induction of nematic order in actomyosin fibres, we perform both linear and weakly non-linear bifurcation analyses. The onset of nematic ordering spontaneously breaks spherical symmetry, yielding distinct equilibrium morphologies governed by the shell's deformability. Axisymmetric configurations, featuring two +1 defects at the poles, emerge via a discontinuous bifurcation, resulting in a globally stable prolate shape, alongside a metastable oblate shape. Non-axisymmetric configurations, featuring four +1/2 defects arranged in a square, arise via a continuous bifurcation. Shell softness drives the first-order character of the transition, while in the limit of infinite stiffness all bifurcations become continuous. Integer defects strongly couple with local mass redistribution, manifesting as shell thinning or thickening, whilst half-integer defects induce no such local deformation. These findings provide a purely mechanical framework for understanding body-axis formation and defect-mediated morphogenesis in biological vesicles.