Pulse at the Temple: Where Age Leaves Its Mark ✎ bioRxiv

Original: "Temple PPG Morphology Demonstrates a Stronger Cardiovascular Age Signal Than Wrist Sites"
· D Liu, A Dutta, S Nadig
b42w:2608.90039 · the paper's page · 2026-08-24 · CC BY-NC-ND 4.0 · independent analysis · 2 min
The shape of the pulse wave at the temple reveals more about vascular aging than the wrist does.

The pulse at the temple beats like a city's main artery: it shows how the roads are aging. At the wrist, the signal looks more like a back street where traffic noise drowns out the important details. Scientists compared these two sites to figure out where age leaves the clearest mark.

An optical sensor shines light through the skin and catches every heartbeat. At the temple it sees 14 age-related features, at the wrist only 3.

Until now it was unclear whether information about vascular aging depends on where you measure. Now it's clear: at the temple, age shows up in 14 stable features of the wave shape, while at the wrist only in 3, and the links at the temple are stronger and more varied. The strongest feature at the temple is a change in the curvature of the pulse wave during systole. Its correlation with age reaches −0.679, comparable to the accuracy of a good medical test.

The wave's curvature shifts the way an old road bends: the stiffer the artery, the sharper the turn.

The secret is that the temple sits closer to the heart than the wrist. The pulse wave reaches it almost without distortion, while at the wrist it has time to reflect off small vessels and lose some information. The analysis confirms this: explaining 85.3% of the variability at the temple takes 5 independent components, while at the wrist just 3 are enough for 100%. In other words, the signal at the temple is richer and less redundant.

The practical payoff is obvious: if wearable devices could pick up the pulse at the temple, they could assess arterial stiffness more accurately without a cuff. That opens the way to glasses, headphones, and patches that continuously monitor vascular aging. But first we need paired measurements in the same people with identical sensors to rule out the influence of different conditions. For now, the pulse at the temple remains the most informative road map you can read age from.

The short-wave fNIRS channels that are usually discarded as noise unexpectedly yielded age correlations up to r = −0.852 at a wavelength of 830 nm.

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blood pressure pulse wave