How Inflammation Ages Cells ✎ bioRxiv

Original: "An inflammatory gene set driven epigenetic clock tracks down disease progression and rejuvenation"
· P Sandor, C Kerepesi, J. P Castro
b42w:2606.90002 · the paper's page · 2026-06-06 · CC BY-NC 4.0 · independent analysis · 1 min
Chemical marks on inflammation genes can reveal biological age and show rejuvenation.

Inflammation works like a hand on a clock: when it's strong, the body ages faster. Scientists have found a way to see that hand. They took 127 genes that switch on during inflammation and looked at the chemical marks next to them. Those marks can predict a person's age.

A chemical mark on a gene is like a bookmark in a book. It doesn't change the text, but it shows whether that page is being read. As we age, the bookmarks shift, and they reveal how old a cell is.

Then the scientists tested this clock on cancer cells. It turned out that cancer pushes the hand forward: the cells look older than they really are. And when the cells were returned to a young state, the hand moved back. So inflammatory marks can be erased, and inflammation-driven aging is reversible.

Now researchers can build such clocks for any genes through the GeneClock Studio website. This will help track aging in various diseases and check whether treatments are working.

In the cancer set of 39 tumor types, samples from a 112-year-old woman had to be excluded to avoid skewing the statistics.

Take the whole work

Not published on arXiv. Here are its page, the PDF and the formalization: you can check it yourself, not only read our account.

Concepts
epigenetic aging gene epigenetic clock aging clock infection immune cell inflammation cancer hormone genomics immunity epidemic wound healing genome chronic disease epidemic model chronological age stem cell embryonic development