How to See the Hidden Shapes of Proteins express

Original: "EMERALD-UI: An interactive web application to unveil novel protein biology hidden in the suboptimal-alignment space"
arXiv:2602.12730 · 2026-02-13 · CC BY 4.0 · 1 min
A new tool reveals that proteins can adopt forms we never noticed before.

Proteins are the molecular machines of life. They fold into complex three-dimensional shapes, like a sheet of paper into origami. But if you fold the paper a bit differently, you get a different figure. Likewise, a protein can take on several forms, and that determines how it works.

Usually, scientists compare proteins by their sequences — chains of amino acids. It's like comparing book texts without looking at the illustrations. But now there's a tool called EMERALD-UI. It shows not only the primary shape of a protein but also alternative versions that hide in "suboptimal" alignments.

Even if a protein's sequence doesn't match perfectly, its shape can still be preserved. EMERALD-UI visualizes such cases, revealing hidden patterns.

It's like looking at the night sky not only through the most powerful telescope but also through a side finder scope: sometimes you see things there that the main lens misses. The tool is free and runs right in your browser.

A protein can have several stable shapes, and switching between them sometimes acts like a molecular switch.

Scientists
William Lawrence Bragg
Concepts
protein design protein structure amino acid sequence Explainable AI bioinformatics genetic code ai drug discovery peptide amino acid medical image analysis protein folding genetic algorithm predictive model medical imaging ai