Why Neurons Can't Be Friends with Everyone express

Original: "Analytically tractable model of synaptic crowding explains emergent small-world structure and network dynamics"
· Makoto Fukushima
arXiv:2603.19320 · 2026-03-16 · CC BY 4.0 · 1 min
The brain follows a simple rule: the more connections a neuron has, the harder it is for it to make new ones.

A neuron in the brain is like a person handing out business cards at a crowded conference. At first, making acquaintances is easy, but as the address book fills up, each new contact requires more effort: there's little room left. The authors based their model on this 'crowding' rule: the more incoming connections a neuron already has, the harder it is to form another one.

In the real brain, synapse density is maintained at a remarkably constant level, as if an invisible regulator were at work.

The one-parameter model yielded an exact solution: the average number of connections grows only logarithmically with network size, and the spread remains bounded. This aligns with the fact that the brain allows neither overload nor underload of neurons. When new connections are added in order of spatial proximity, a broad distribution of connection lengths emerges, close to a power law — without any explicit rules favoring long or short connections.

Adding random 'shortcuts' turns the network into a small world: any two neurons are connected through a small number of intermediaries.

The authors then showed that the statistics of connections determine the boundaries of stable states in the dynamics of threshold networks. Local clustering, in turn, influences the appearance of long-lived unstable states near these boundaries. Thus, simple local mechanics of connection growth explain the macroscopic organization and dynamics of neural circuits.

The logarithmic growth of connection numbers means that doubling the network size increases the average number of connections by only one or two units, the brain is surprisingly frugal with new contacts.

In Peter Watts's novel 'Blindsight,' the alien mind is built on different principles of connectivity than humans — the crowding model shows how tightly local constraints shape thinking.

Concepts
neural network memory architecture network complex systems neural networks in spatial mapping brain connectivity synapse emergent complexity modeling emergent collective learning entropy driven self assembly density generative model normalizing flows central limit theorem Liebig's Law of the Minimum collective behavior Mendel's Law of Segregation Braess's paradox in biology neuron principle of maximum entropy neurotransmitter