How Bacteria Stick to Surfaces express

Original: "Wetting-coupled phase separation as an energetic mechanism for active bacterial adhesion"
arXiv:2601.06754 · 2026-01-11 · CC BY 4.0 · 2 min
In a mixture of two liquids, bacteria find invisible traps and stick to the walls.

A drop of oil in water behaves like a tiny ball: it seeks the spot with the least energy. If a wall is nearby, the drop often sticks to it, just as a raindrop spreads on glass. In a mixture of two immiscible liquids, such as polyethylene glycol and dextran, tiny droplets of one liquid form inside the other. As these droplets settle on a wall, they create a dip in the energy landscape, like a hollow on a surface that a ball rolls into.

Bacteria swimming in such a mixture act like balls. When a droplet sticks to the wall, an energy well forms next to it. A bacterium that happens to swim in can't get out: it sticks to the surface. Scientists ran experiments with Pseudomonas aeruginosa and Staphylococcus aureus in a polyethylene glycol-dextran mixture. They found that bacteria indeed accumulate at the wall exactly where droplets have attached. Computer simulations confirmed: droplets create traps that hold bacteria.

But bacteria have their own motion. They swim using flagella — thin filaments that rotate like propellers. This motion can both help and hinder. If there are few droplets, bacteria actively swim toward the wall and fall into traps. If there are many droplets, they start swirling — self-rotating droplets form. The rotation creates a fluid flow that pushes bacteria away from the wall. So the number of droplets decides whether bacteria stick or not.

In a mixture of two liquids, bacteria stick not because of charge or chemistry, but because of simple physics: droplets create energy wells, like dips on a surface.

This discovery helps us understand how bacteria form biofilms — dense communities on surfaces, such as on medical implants or pipes. Knowing that liquid droplets can serve as traps, we might learn to control bacterial adhesion: for example, by adding substances that change droplet wetting and thus prevent bacteria from settling.

Pseudomonas aeruginosa bacteria can swim at speeds up to 60 micrometers per second: that's about 100 body lengths per second. For comparison, a human swimmer covers about one body length per second.

Concepts
water splitting microorganism swimming dynamics phase separation microbial collective motion flagella liquid water antibiotic resistance bacterium lubricant binding energy biofilm suspension surface tension hydrogen bond soil moisture evaporation fluid dynamics in porous media wound healing liquid molecular interaction