object

flagella

Long, whip-like appendages that cells use for locomotion through fluids.
40 related articles

Description

Flagella are long, whip-like appendages that protrude from the cell body of many bacteria, archaea, and eukaryotic cells. They are the primary organelles of motility, enabling cells to swim through liquid environments. In bacteria, the flagellum is a helical filament that rotates like a propeller, driven by a motor embedded in the cell membrane. In contrast, eukaryotic flagella (such as those in sperm cells) bend in a wave-like manner, powered by molecular motors called dyneins.

History

The existence of flagella was first observed by Antonie van Leeuwenhoek in the 17th century, who described them as 'little legs' on bacteria. The molecular mechanism of bacterial flagellar rotation was elucidated in the 1970s by Howard Berg and others, who used tethered cell experiments to show that the flagellum rotates.

How it works

Bacterial flagella are composed of a protein called flagellin, which self-assembles into a hollow tube. The motor at the base, powered by the flow of protons or sodium ions across the cell membrane, rotates the filament. The rotation direction can be switched, causing the bacterium to 'run' (swim smoothly) or 'tumble' (change direction). Eukaryotic flagella have a complex internal structure called the axoneme, consisting of nine pairs of microtubules arranged around a central pair. Dynein motors cause the microtubules to slide past each other, producing a bending motion that propagates along the flagellum.

In practice

Understanding flagellar motility is important in medicine for developing treatments against bacterial infections, as motility is often a virulence factor. In biotechnology, flagella are studied for their potential in creating micro-robots and for understanding self-assembly processes.

Fun fact

The bacterial flagellar motor is one of the most efficient rotary machines known, capable of rotating at speeds up to 100,000 revolutions per minute, and it can change direction in less than a millisecond.

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