concept

molecular interaction

Forces between molecules that influence their arrangement and behavior on a surface.
44 related articles

Description

Molecular interactions are the collective forces between molecules that determine their arrangement, dynamics, and behavior on surfaces and in bulk materials. These interactions include van der Waals forces, hydrogen bonds, electrostatic forces, and hydrophobic effects, which together govern phenomena such as adhesion, wetting, self-assembly, and the folding of biological macromolecules. Understanding these forces is essential for explaining why materials behave the way they do, from the crumpling of paper to the formation of cellular membranes.

History

The study of molecular interactions dates back to the 19th century with van der Waals' work on real gases, but the modern understanding of specific forces like hydrogen bonding was developed by Linus Pauling and others in the 1930s.

How it works

Molecular interactions arise from the electromagnetic forces between charged and polar regions of molecules. Van der Waals forces, for example, result from transient fluctuations in electron distribution, while hydrogen bonds involve the sharing of a hydrogen atom between electronegative atoms. On surfaces, these interactions dictate whether molecules spread, cluster, or form ordered layers, depending on the balance of attractive and repulsive forces. The interplay of these forces can be modeled using computational chemistry and surface science techniques.

In practice

These principles are applied in designing self-assembling materials, improving drug delivery systems, developing non-stick coatings, and understanding biological processes like protein folding and membrane formation.

Fun fact

Geckos can climb vertical surfaces thanks to van der Waals forces between their toe hairs and the surface, a phenomenon that has inspired synthetic adhesives.

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Related articles · 44

Layer Memory: How MXene Remembers Being Flipped Through
A stack of pages that has been flipped through many times remembers it: some sheets lie flat, others stick up, and creases remain here and there. Layered materials behave much the same way when ions enter them.
Materials2026-09-013 minarXiv:2609.01872
A Ship in a Bottle: How to Trap a Quantum Spin in a Layered Crystal
A ship in a bottle is assembled from the inside, not the outside: masts and sails are pulled through the narrow neck, and once inside the glass they settle into the right pose on their own. Chemists have done something similar with a single cobaltocene molecule, which they pulled into the gap between layers of a two-dimensional crystal.
q-bio.CB2026-08-282 minarXiv:2608.27833
Why Cells Invade as a Stream or a Clump
The orchestra starts playing, but each musician has their own tempo. If everyone plays at roughly the same speed, the music flows in a continuous stream. But if one group of instruments plays noticeably slower than the rest, the sound gathers into a dense clump that slowly moves forward.
Four Conductors of the Cellular Orchestra: How Epithelium Chooses Its Path to Fluidity
Epithelium lines our organs like tiles on a floor. At rest, cells cling to each other, and the tissue is elastic. But during embryonic development, wound healing, or tumor growth, this layer begins to flow like thick honey. What exactly triggers such softening?
Biological Physics2026-08-092 minarXiv:2608.08571express
Why biological recognition doesn't snap but smoothly switches
When an antibody meets a virus, it doesn't latch on with a single death grip. Rather, it's like two bunches of grapes tumbling in water, catching each other with dozens of short tendrils. Each tendril is weak on its own, easily torn by the thermal jitter of water molecules, but together they hold tight.
Still Particles Come Alive in a Crowd
At a concert, moving through a dense crowd is tough — the tighter the pack, the less you want to move. That's how active matter usually behaves: swarms of bacteria or robot flocks freeze in tight quarters. But one research group found the opposite effect.
Chemical Physics2026-08-032 minarXiv:2608.02865express
Weak Molecular Bonds Step Out of the Shadows
Inside every cell, things are constantly meeting and parting. Some pairs hold tight, like Velcro, while others barely touch, like pollen on the wind. These fleeting touches, where the binding strength is comparable to a grain of salt dissolving in a glass of water, govern many of the cell's signals and decisions.
Quantum Gases2026-07-281 minarXiv:2607.25777express
Flip-Flop Molecules: Turning Polar Particles into Quantum Chess Players
A polar molecule is like a tiny dumbbell with opposite charges at its ends. Normally, such particles quickly stick together or fly apart when they meet — electric forces are too strong. But the authors of the work found a way to turn this aggressiveness into a controlled game.
Weight Geometry: The Conductor of Memory in Complex Systems
Why do some systems, from gene networks to air travel, preserve imprints of the past longer than others? For a long time, network science blamed topology: the number of connections, modularity, spectrum. But two networks with the same skeleton can remember and forget in completely different ways.
Chemical Physics2026-06-072 minarXiv:2606.08619express
Chemistry Without Points: A Field Instead of Active Sites
A kitchen sponge soaked in syrup: in some spots there's more syrup, and your finger sticks right away; in others, it barely touches. That's roughly how a catalyst surface works. Molecules don't react everywhere but at especially sticky points — active sites.
Cell Divisions Quench Avalanches in Living Tissue
A lump of plasticine, when kneaded, behaves like an amorphous solid — not a crystal, but not a liquid either. Inside such a material, avalanches can occur: one tiny rearrangement triggers neighboring ones, and a wave sweeps through the entire sample.
Atomic Physics2026-05-121 minarXiv:2605.12767express
Radioactive Molecules — Hunters for Unknown Particles
The Standard Model is a set of rules for all known particles. But it says nothing about dark matter, which makes up a quarter of the Universe. To find it, you don't need to build city-sized colliders. Radioactive molecules act like sniffer dogs: their incredible 'scent' picks up the faintest traces of unknown forces that slip past giant machines.
Charged Particles in Water: Why Like Attracts Like
Two grains of salt fall into a glass of water. They dissolve, and sodium and chloride ions spread throughout the volume. The schoolbook truth is simple: like charges repel, opposite charges attract. But recent experiments with tiny spheres in liquids have revealed a picture that breaks this rule.
Fluid Dynamics2026-05-092 minarXiv:2605.08906express
How Liquid Elasticity Reshapes the Particle Trap
A drop of thick shampoo falls into water and freezes into a strange rope. A liquid that both flows and springs back is called viscoelastic. In it, tiny particles under ultrasound behave quite differently than in water. Viscoelasticity is a material's ability to both spread like honey and return to shape like rubber.
Biological Physics2026-05-081 minarXiv:2605.07109express
The Gold-Digger Cell
A cell crawls over a gel (sometimes viscous, sometimes elastic) and decides on its own when to speed up. It doesn't just glide: its internal chemical motor (noise in gene expression can affect the production of 'fuel') pushes the leading edge, while the rear detaches from the substrate.
Biological Physics2026-04-231 minarXiv:2604.22024express
Mitochondria in a Traffic Jam: How Shape Decides a Neuron's Fate
Inside every neuron, there's a long, thin channel, the axon, through which signals travel from the cell body to other cells. To keep this channel working, mitochondria constantly shuttle along it. These tiny organelles produce energy and move in both directions, like cars on a narrow road.
HEP Theory2026-04-191 minarXiv:2604.17216express
Bubbles in a Superfluid
In a pot of boiling water, steam bubbles rise and pop. In the quantum world of a superfluid, bubbles behave differently: they can collide and give birth to vortices — tiny swirling flows, like whirlpools in a river. Scientists modeled such a liquid using a holographic approach.
Quantum Gases2026-04-152 minarXiv:2604.13370express
A Cloud of Atoms That Holds Itself Together
A cold cloud of atoms is like a swarm of fireflies drawn to one another. The attraction between atoms tries to pack them into a single dense ball. But quantum jitter, the unavoidable motion of particles, keeps the ball from collapsing. When the attraction is strong, the cloud breaks into separate clumps.
Materials2026-04-101 minarXiv:2604.09758express
Smell Is Not a Single Formula
The nose is an amazing instrument. A single coffee molecule entering a nostril can awaken a memory of a morning kitchen. Another, nearly identical in shape, smells like rotten eggs.
Mesoscale2026-04-091 minarXiv:2604.07946express
Water in Nanopores: Layer by Layer or All at Once
In a narrow gap between two plates, water from humid air collects on its own: this is capillary condensation. If the gap is only a few nanometers wide, water no longer behaves like a continuous liquid: every molecule counts.
High Energy2026-04-061 minarXiv:2604.04659express
Why Power Laws Are Everywhere
Toss a handful of sand on the floor: there are few large grains, many medium ones, and even more tiny ones. This skew, where small events are common and large ones are rare, is described by a power law. It shows up in city sizes, earthquake magnitudes, and citation counts of scientific papers.
Chemical Physics2026-04-031 minarXiv:2604.03464express
How Water Dances with Carbon Rings
A water molecule, finding itself near a carbon ring, starts to vibrate, and immediately falls under the sway of an invisible conductor. The ring's electron cloud, like a maestro, dampens some vibrations while amplifying others.
How Soap Changes the Shape of a Drop
A drop of oil in water, coated with soap molecules, behaves differently from a bare drop. Soap molecules are tiny rods: one end loves water, the other loves oil. In a quiescent fluid, they stand on the surface like a picket fence, lowering the surface tension — the force that pulls the drop into a sphere.
Fluid Dynamics2026-03-161 minarXiv:2603.15896express
How Rain Launches Microplastics into the Air
The Sun drives the water cycle, and rain returns it to the ground. But now, every drop is a tiny hammer striking the surface. Floating plastic particles (microplastics, mostly carbon) upon impact jump up like popcorn kernels on a hot skillet. But instead of popping, they get wrapped in a thin water film and turn into weightless beads.
How droplets inside cells shape membranes
Inside a living cell, droplets float that don't mix with the surrounding fluid, like oil in water. These droplets aren't just passive clumps; they actively press on membranes and make them bend. Scientists observed this process in living plant cells, reproduced it in a test tube, and simulated it on a computer.
Soft Particles Assemble into Patterns
A drop of water with tiny particles dries on a table. The water evaporates, leaving the particles behind, and they arrange into a pattern, like sand after the tide. But if the particles are soft, the pattern turns out quite different. Researchers studied this process under a microscope, varying only one property of the particles: their elasticity.
Why Amorphous Bodies Bend Differently
When you press your finger on a piece of soft putty, it obediently dents and then slowly returns to its original shape. But if you press on a window pane, it either holds or cracks — no smooth deformation. Both materials are amorphous: their atoms are not arranged in a strict crystal lattice like in metal. Yet they behave completely differently.
How crosslinking proteins keep cells in shape
Inside every cell, there is a scaffold of filaments, like construction scaffolding that gives the cell its shape and allows it to move. These filaments are connected by crosslinking proteins: some simply hold them together like ropes, while others act as tiny motors that crawl along the filaments and pull them toward each other.
Fidgety Molecules: How Internal Order Changes Behavior
A drop of ink in a glass of water spreads out on its own. But if the ink were made of tiny motors, they wouldn't just spread: they'd crawl, jostle, and cluster into swarms. Such self-propelled particles are called active. You can assemble them into molecules like beads on a bracelet. And here's the surprise: the order of beads on the bracelet changes everything.
Why Magnetic Fluid Forms Threads
In a jar of oily liquid float millions of tiny magnetic grains: each about the size of a bacterium. Switch on a magnet, and the grains, like obedient little soldiers, line up into long threads. But why do they form threads rather than clumps? It turns out it's not just about magnetism.
Fluid Dynamics2026-01-262 minarXiv:2601.18465express
The Hidden Force on Leaves
A water droplet races across a taro leaf like a bead on a freshly waxed floor. But it doesn't just glide: it picks up electricity. Thirty years ago, scientists explained why lotus leaves stay dry: their surface is covered with microscopic bumps that trap air. Now it turns out that water on leaves has another, hidden power.
Biological Physics2026-01-262 minarXiv:2601.18669express
Swimming Cells Choose Their Viscosity
A swimmer in a pool of syrup moves differently than in clear water: each stroke is harder, but you can push off more strongly. Roughly the same goes for single-celled organisms — tiny rowers that propel themselves through fluid using flagella.
How a Drop with Nanoparticles Cracks on Glass
A coffee drop on a table dries and leaves a ring — coffee particles gather at the edge. But if charged nanoparticles float in the drop, the picture becomes richer: the deposit cracks like mud in a dried-up puddle. Physicists studied how the particle charge and the surface on which the drop dries change these cracks.
Fluid Dynamics2026-01-251 minarXiv:2601.17674express
Turbulence That Doesn't Get in the Way of Order
Bacteria in a drop of water jostle and swim: each on its own, but together they create patterns. With weak motion, the fluid churns like soup on a high flame: vortices collide, and the flow direction changes every second. This is called bacterial turbulence.
Atomic Physics2026-01-232 minarXiv:2601.17144express
Quantum Entanglement: Born in Collisions
In the quantum world, a collision between particles doesn't destroy their individuality but ties them into an inseparable knot: internal states and motions become intertwined like threads in an intricate tapestry.
Biological Physics2026-01-212 minarXiv:2601.15477express
Proteins bend the membrane the way a spoon bends the film on milk
The membrane of a living cell is not a rigid shell but a pliable film with thousands of proteins embedded in it, like raisins in dough.
q-bio.PE2026-01-201 minarXiv:2601.13947express
How the Weak Win: Fleeing a Neighbor Saves the Species
Two species of bacteria share a single Petri dish. Both eat the same food, and by all rules, one should outcompete the other. But in reality, they often live together for years. The secret lies in knowing when to leave. Bacteria don't stay put. When a stranger appears nearby, they start moving faster.
Chemical Physics2026-01-201 minarXiv:2601.14187express
Light Changes the Speed of Chemistry
An ordinary chemical reaction is like a ball rolling down a hill: it has one natural path. But if you place molecules in a tiny mirrored box, an optical microresonator, the light inside starts to interfere with the ball's motion. It can nudge it, hold it back, or even split its trajectory. In a new study, physicists traced exactly how this happens.
How Bacteria Stick to Surfaces
A drop of oil in water behaves like a tiny ball: it seeks the spot with the least energy. If a wall is nearby, the drop often sticks to it, just as a raindrop spreads on glass. In a mixture of two immiscible liquids, such as polyethylene glycol and dextran, tiny droplets of one liquid form inside the other.
Biological Physics2026-01-091 minarXiv:2601.05907express
Waves That Keep Their Formation
Inside a fertilized frog egg, waves ripple, like ripples on water, but made of proteins that command cell division. These waves travel millimeters, even though the egg itself is less than a millimeter across. Previously, it wasn't understood why they didn't fall out of sync. It turns out the waves clear their own path.