A molecule works like a marketplace: electron shoppers enter through two gates (contacts) and head for stalls with the most attractive goods — the chemically active spots. Previously, current was thought to spread evenly, but it turns out up to 90% of all flow rushes through these 'hot spots'. Reactive centers become superconducting highways inside the molecule.
Precise quantum modeling revealed that at ordinary temperatures with fast heat dissipation, especially in proteins with their tangled structures, everything is governed by entropy (a measure of disorder). Conductivity boils down to a single quantity — the Fukui function, which exactly shows each site's chemical activity.
This bridge promises breakthroughs: knowing a protein's reactivity lets you steer its electrical signals with drugs or build protein-based sensors. Bioelectronic chips, where the flexibility of life meets the speed of machines, are no longer sci-fi.
Enzyme active sites are the hottest 'hot spots' for conductivity: almost all the current flows through them.
Protein chips aren't new to science fiction: the biocomputers in William Gibson's "Neuromancer" worked exactly that way.