Gas clouds where stars are born turned out to be layered, just like a cake. Grab a fork for the sponge, a spoon for the cream, a knife for the nuts. That's exactly how the glowing colors of hot gas (spectral lines) work: some hint at near-vacuum, others at clumps squeezed a thousandfold. So measurements of one nebula never added up: each instrument tasted its own little piece and called it the whole cake.
Once astronomers blended all the data, the big picture emerged. The density of interstellar gas swings from nearly nothing to extreme compression.
That explains why temperatures ping-pong inside nebulae. Even in the Orion Nebula, studied since the 19th century, gas hundreds of times denser was just found lurking. JWST data and computer models back this up: such wild density contrasts are common in other galaxies. So our mass and chemical composition calculations need a rethink, and those are the bedrock of how we understand galactic life.
Even in the Orion Nebula, which we've been watching since the 1800s, gas hundreds of times denser was only just discovered, and that meant recalculating the cloud's entire mass.