Born in England, studied at Cambridge but did not receive a degree, as women were not awarded degrees at that time. Moved to the US, to the Harvard Observatory, where she worked under Harlow Shapley. In 1925 she defended her doctoral dissertation at Radcliffe College. Later became a professor at Harvard, the first woman to hold this position on a full-time basis. Married to astronomer Sergei Gaposchkin. Received many awards, including the Henry Norris Russell Prize.