Lateral gene transfer is the movement of genetic material between organisms other than by vertical inheritance from parent to offspring.Horizontal gene transfer is a mechanism by which genetic information moves between organisms not through sexual reproduction or inheritance from parents. It is especially characteristic of prokaryotes (bacteria and archaea), but also influences the evolution of eukaryotes. Unlike slow mutations, horizontal transfer allows organisms to acquire ready-made genes, enabling rapid adaptation.
The concept emerged in the early 20th century. Frederick Griffith in 1928 described the transformation of pneumococci but did not know about DNA. Later, in 1944, the experiment by Avery, MacLeod, and McCarty proved that the transforming agent is DNA. The study of LGT intensified with the development of genomics, when it became clear that many bacteria have mosaic genomes with foreign regions.
At the molecular level, LGT includes several stages: exit of DNA from the donor (active secretion, cell lysis), existence of extracellular DNA (often in complex with proteins), penetration into the recipient (through membrane channels or receptors), and integration into the genome by homologous recombination or via site-specific recombinases. Many mobile genetic elements, such as transposons and integrons, play an intermediary role. The frequency and success of transfer depend on phylogenetic distance, ecological niche, and the restriction-modification systems of the host cell.
Explains the rapid spread of antibiotic resistance among bacteria and is used in genetic engineering to create GMOs.
The human genome contains genes obtained from viruses and bacteria millions of years ago. About 8% of our DNA consists of remnants of ancient viruses that once integrated into the genome of our ancestors.


