Born in Erlangen to mathematician Max Noether. She studied languages and planned to become a teacher, but later turned to mathematics. Studied at the University of Erlangen, where initially she only audited lectures because women were not allowed to be full students. Later moved to the University of Göttingen, where she worked with David Hilbert and Felix Klein. Due to discrimination, she was long unable to obtain a position, teaching under Hilbert's name. In 1933, being Jewish, she emigrated to the USA, where she taught at Bryn Mawr College and collaborated with the Institute for Advanced Study. She died in 1935 after an operation. Recognition came to her largely posthumously.