A tiny blood vessel that connects arteries and veins, allowing exchange of substances.A capillary is the smallest type of blood vessel in the circulatory system, connecting arterioles to venules. Its thin walls, composed of a single layer of endothelial cells, allow for the efficient exchange of oxygen, carbon dioxide, nutrients, and waste products between blood and surrounding tissues. Capillaries are so narrow that red blood cells must often pass through in single file, maximizing contact with the vessel wall.
The existence of capillaries was first proposed by William Harvey in the 17th century, but they were observed directly by Marcello Malpighi in 1661 using a microscope.
The exchange occurs primarily through diffusion driven by concentration gradients, as well as through bulk flow due to hydrostatic and osmotic pressure differences across the capillary wall. Small molecules like oxygen and carbon dioxide diffuse directly through the endothelial cells, while larger molecules may pass through gaps between cells or via vesicles. The balance of pressures, described by the Starling equation, determines whether fluid moves into or out of the capillary.
Capillaries are central to drug delivery research, as understanding their permeability helps design nanoparticles that can cross the blood-brain barrier or target tumors.
The total length of capillaries in an adult human body is estimated to be about 60,000 miles, enough to circle the Earth more than twice.






