substance

atp

Adenosine triphosphate, the molecule that fuels cellular processes, measured in energy units.
14 related articles

Description

Adenosine triphosphate (ATP) is the primary energy currency of all living cells. It stores and transports chemical energy within cells, powering processes such as muscle contraction, nerve impulse propagation, and biosynthesis. The molecule consists of an adenosine group and three phosphate groups; the energy is released when a phosphate bond is broken, converting ATP to adenosine diphosphate (ADP).

History

ATP was discovered in 1929 by Karl Lohmann, and its role as the energy currency was established by Fritz Lipmann in 1941. The mechanism of its synthesis via oxidative phosphorylation was clarified by Peter Mitchell's chemiosmotic theory in 1961.

How it works

ATP is produced in cells through processes like cellular respiration and photosynthesis. The energy from breaking the high-energy phosphate bonds is harnessed by enzymes to drive endergonic reactions. The ATP-ADP cycle continuously regenerates ATP from ADP and inorganic phosphate, using energy derived from nutrient breakdown or light.

In practice

ATP is used in bioluminescent assays to measure cell viability and in medical research to study metabolic disorders. It is also a target for drug development in cancer and infectious diseases.

Fun fact

A single human body produces and consumes about 50 kilograms of ATP per day, but the total amount present at any moment is only about 50 grams, meaning each ATP molecule is recycled thousands of times daily.

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Related articles · 14

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Atomic Batteries from a Fusion Reactor
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Plant Quenches Its Internal Light in 60 Picoseconds
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Molecular Qubits: Long Memory at Room Temperature
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Living Things Glow with Heat, Like the Sun
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Molecular Attoscope Captures the Dance of Electrons and Nuclei
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Breathing Contact and the Memory of Decay
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A Blow to the Building Blocks of Life
Cometary ice slams into the young Earth. The pressure at the impact point is like stacking six aircraft carriers on your thumbnail. In the lab, such conditions are reproduced by squeezing a tiny sample between two rotating anvils. This time, adenosine monophosphate — one of the letters of future RNA — was placed under the anvils.
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How a Drug's Charge Alters Its Path Under the Skin
After an injection under the skin, a drug doesn't just spread out like ink in water. Antibody molecules carry an electric charge, and that charge makes them interact with surrounding tissues — much like a magnet attracts or repels iron filings.