hippocampus

A jazz trio plays in the dim light of a club. The pianist leads the melody, the bassist holds the rhythm, and the drummer sprinkles out rolls. If you listen only to pairs of musicians, you can catch how the pianist adjusts to the bass or the bass to the drums.

In 2023, in Belgium, 101 people aged 50 to 69 spent several days in a lab where their brains were scanned, their sleep was recorded, and they were asked to solve memory and attention tasks. That is how the COFITAGE dataset was born, describing each participant from five angles: molecular, structural, physiological, genetic and cognitive.

In the dark room of the scanner, a person watches for rare flashes on a screen. An infrared camera records their pupil a thousand times per second, while an MRI scanner simultaneously logs which brain areas light up. In this way, 89 volunteers aged 19 to 78 helped scientists see how the pupil becomes a display on which the brain outputs two different signals.

The brain as a house built too spacious: lovely to live in, but expensive to maintain. Parkinson's disease is usually pictured as the destruction of that house, with neurons dying and structures shrinking.

In a school report card, each grade speaks for itself, but you can only tell how a student is doing overall by looking at the full report. For drugs that act on the brain, such a report card was missing for a long time. Every test on a miniature brain grown in a dish gave its own signal: some genes switched on, others switched off, electrical impulses sometimes sped up and sometimes went quiet.

An older person says with confidence that the word "sunflower" was on the list, even though only "almond" was there. Both words are tied to oil, and that semantic thread was enough for the brain to fill in the memory. Memory works like a compass: one needle points to meaning, the other to the order of events. With age, one of the needles starts to outweigh the other.

The classroom goes quiet after the lesson, but the echo still rings in the child's head: faces, objects, places. It is this echo, not the lesson itself, that decides what will stay in memory. For the first time, researchers have caught it in children aged 6 to 17. Children memorized scenes inside an MRI scanner: they were shown a room, then an object or a face in a particular spot.

A person talks about a familiar face, and their speech becomes a mirror reflecting the workings of memory. In patients with temporal lobe epilepsy, this mirror sometimes grows cloudy: words come more slowly, phrases break off, pauses hang in the air. Doctors have long heard such complaints, but standard tests, where you have to name a picture or recall a list of words, often come back normal.

A geologist walks along a mountain slope, running an instrument over the rocks. The instrument shows where iron ore lies beneath the surface and where the rock has cracked. A magnetic map of the brain works in much the same way: it reveals where iron has accumulated in the tissues and where the sheath of nerve fibers is damaged. After a concussion, such imaging is especially important.

An orchestra of thirty-six instruments plays almost in unison. The conductor tries to pick out which voice is carrying the melody, but the sounds blur together, and each successive bar only adds doubt.

Getting lost in a hall of mirrors is easy: every wall reflects another, and you feel like you've been here before. The brain gets similarly confused when surrounded by many similar places. Neurons responsible for the spatial map can fire the same signal for two different corners of a room. This is called spatial ambiguity.

The brain is like an orchestra, with the cortex as the conductor and the thalamus as the first violin. The thalamus relays signals from the eyes to the visual cortex. But the cortex can also send commands back, tuning the thalamus for the task at hand. This was once a hypothesis, but now it's been tested in humans.

A doctor spends years learning to recognize diseases from brain scans. First, they excel at spotting signs of aging, then they master tumors, and suddenly they start confusing what they knew before. Many neural networks behave much the same way: new knowledge overwrites the old.

A city at night: lights on in some windows, dark in others. If you connect with lines the windows that light up simultaneously, you get a web of connections. Researchers studied such a web in tiny brain organoids — living clusters of nerve cells grown in the lab.

Imagine an old theater in the damp fog. On the stage, a scattering of actors, but only one is caught by the spotlight beam, made to freeze in the bright patch. The rest billow in the dim light, ready to dissolve at any moment.

You're telling a friend a story, and their brain seems to tune into your wavelength — the same regions light up in sync with your words.

A quantum particle traveling around a closed ring leaves two distinct 'records' along its path. The first is like a fingerprint on a doorknob: it remains unchanged no matter how many times you turn the knob, and it only tells you about the shape and material.

A supermarket cashier at rush hour doesn't memorize every scanned item: they keep the running total in their head and watch the queue. The brain allocates its resources similarly: the expensive, precise cortex (responsible for deliberation) and the simpler, economical subcortical nuclei (where habits live) work in tandem.

In a grand courtroom, a meeting is in session. Hundreds of translator-neurons simultaneously hear fragments of phrases, and must piece them into a single coherent picture. This is exactly how large brain networks turn scattered signals from the eyes into a unified object image.

A tightly stretched sheet lies on a table for days. Outwardly it's still, but the fabric fibers retain tension — loosen one edge slightly, and wrinkles will run across it, rearranging the whole pattern. That's roughly how a layer of epithelial cells behaves at rest. It doesn't just freeze; it accumulates mechanical stress — a kind of cellular memory of past movements.

Engineers are building a car. Some assemble an exact replica of the engine, every piston and spark plug, but the car doesn't move: there's no steering wheel or wheels. Others build a fast self-driving go-kart, but its engine is made of playdough and doesn't resemble a real one. This is roughly the situation in brain science.

An orchestra at its first rehearsal without a conductor. Violins come in at the wrong time, brass is late, and instead of a symphony, you get cacophony. That's roughly how a computer model of the brain behaves when you remove special cells — von Economo neurons.

A person hunting for keys mentally runs through places where they might be. A bird that tucked hundreds of seeds into crevices in autumn retrieves them flawlessly in winter. How can a brain hold so many addresses when all birds have roughly the same number of neurons? The answer lies in geometry.

A summer meadow surfaces in memory not just as a picture — along with it come the scent of grass and the warmth of the sun. The brain glues sensations into a single image, and that image holds up better than any one sensation alone. But exactly how neurons stitch the visual to the olfactory has long been a mystery.

The brain constantly juggles tasks: it reacts to a sharp sound, solves an equation, or drifts into daydreams. Scientists have long suspected that switches between different "scenarios" of neural network activity underlie this, but extracting them from the chaos of electrical signals was difficult.

The brain is like a multi-story building: lower floors process simple signals, while upper floors assemble them into complex perceptions. Scientists have long suspected that this order is tied to how neurons work together. But exactly how has remained a puzzle.

Brain aging is like the wear and tear on a bridge: cracks appear unnoticed, but if you reinforce the supports in time, the structure lasts longer. Three ordinary things turned out to be such supports — handgrip strength, the ability to move for a long time without breathlessness, and lung capacity.

Speech is like an orchestra where every note must sound at just the right moment. The brain turns a thought into a chain of sounds in a fraction of a second, and until now it was unclear how it manages this hierarchy — from individual sounds to syllables to whole words.

A mouse brain contains about 70 million neurons, and the connections between them are far from evenly distributed: some cells have only a couple of dozen contacts, while others have thousands. It's like a city with quiet alleys and bustling squares. But until now, it was unclear how this unevenness affects the brain's actual function.

The brain is like a sprawling city: districts-regions communicate via streets-neural pathways. If traffic lights at an intersection fail, traffic grinds to a halt. Similarly, in the brain, when bundles of nerve fibers (white matter) malfunction, distant regions stop working in concert, and thought stalls.

A language model is a multi-layered structure where each layer processes words in its own way. At the start of training, layers are chaotic, but gradually they organize into two teams. The first team works simply: its internal geometry smooths out, becoming less tangled. The second remains complex and intricate.

At night, the brain doesn't switch off. Instead, it sorts through the day's events like a librarian arranging books on shelves. But where do those strange, sometimes nonsensical dream images come from? Many have assumed they're just random noise with no meaning. A new computer model shows that randomness doesn't hinder: it helps.

In the northern part of Arabia Terra, there are fields that look like a giant brain: ridges and troughs wind like convolutions. On Earth, similar patterns form in cold regions when water in the soil freezes and thaws, causing stones to sort themselves into stripes. But the Martian ridges are taller — averaging 3.29 meters — while Earth's mechanisms produce less than half a meter.

When moving to a new apartment, a person doesn't relearn how to open doors or turn on lights. Experience from the old home transfers automatically: a kitchen is a place with a stove and a sink, a bedroom is a place with a bed. The brain doesn't store an exact map but a flexible schema that it overlays onto unfamiliar space. Scientists have built a computer model of this transfer. It has two levels.

Over the course of a day, the brain accumulates impressions the way a room accumulates stuff. At night, during deep sleep, it doesn't just rest: it tidies up: it sorts through the day's events and decides what to keep and what to toss. Scientists built a computer model of the brain that learns from a few examples during the day and 'replays' them at night, as if dreaming.

You're trying not to think about the argument you had this morning, but vivid images keep popping into your head. At the same time, you're preparing a report and holding numbers in your mind. It doesn't go well: memory interferes with work, and work prevents forgetting. Scientists set out to see how the brain copes with this dual load in people with varying levels of anxiety.

A pea-sized brain region brings a rat to a halt mid-step. A laser beam hits light-sensitive cells, and the animal stops as if it hit an invisible wall. This is the rostral pedunculopontine nucleus — a cluster of neurons in the brainstem that controls movement. The authors built a low-cost setup with a camera and a mini-computer.

Silence in the operating room. The surgeon slowly lowers a needle thinner than a human hair into the patient's brain. At its tip is not a point but a whole palisade of nine hundred sixty microscopic microphones. Each one listens to its own tiny patch of gray matter.