Defended his doctoral dissertation at George Washington University under Gamow. In the famous paper with Bethe and Gamow (the αβγ paper), it was Alpher who carried out the main calculations. Predicted the temperature of the cosmic microwave background at about 5 K (later refined to 2.7 K). Worked at the Johns Hopkins Applied Physics Laboratory, then at General Electric and Union College. Received the National Medal of Science in 2005.