
The biological membrane that encloses a cell, controlling the passage of substances in and out.The cell membrane is a biological lipid bilayer that encloses the cell, acting as a selective barrier between the interior and the environment. It controls the passage of ions, molecules, and signals, and is essential for maintaining cellular homeostasis, communication, and energy production. Its physical properties—fluidity, curvature, and permeability—are critical to many cellular processes.
The fluid mosaic model was proposed by S. J. Singer and Garth Nicolson in 1972, describing the membrane as a fluid lipid bilayer with embedded proteins.
The membrane is composed of phospholipids with hydrophilic heads and hydrophobic tails, forming a bilayer in water. Embedded proteins act as channels, pumps, and receptors. The membrane's fluidity allows proteins to move laterally, enabling dynamic responses. Curvature and tension are regulated by the cytoskeleton and by local protein interactions, which can drive vesicle formation, cell movement, and division.
Understanding membrane mechanics is crucial for drug delivery (e.g., liposomes), antibiotic design, and tissue engineering.
Cell membranes can 'freeze' into a gel-like state at low temperatures, which is why some bacteria adjust their lipid composition to maintain fluidity in cold environments.












