law

Starling's law

Starling's law states that fluid exchange across capillaries depends on hydrostatic and osmotic pressure gradients.
31 related articles

Description

In 1914, English physiologist Ernest Henry Starling, while studying an isolated dog heart, discovered a fundamental relationship: the force of cardiac muscle contraction is directly proportional to its initial length before contraction. This property was called the "law of the heart" or the Frank–Starling mechanism (German physiologist Otto Frank had described it earlier for skeletal muscles). The basis is the optimization of overlap between actin and myosin filaments in muscle cells during moderate stretch. The law explains how the heart instantly adapts to changes in venous return without involvement of the nervous system.

History

Otto Frank in 1895 showed on frog skeletal muscles that contraction force depends on the initial fiber length. Ernest Henry Starling in 1914, working with a dog heart preparation, demonstrated that the same principle applies to the myocardium. In the 1950s, with the development of electron microscopy, Andrew Huxley and Hugh Huxley proposed the sliding filament model, explaining the mechanism at the molecular level. Today, Starling's law is the foundation of clinical cardiology and circulatory physiology.

How it works

The law is used to assess cardiac function: the Starling curve is used to judge myocardial contractility. In intensive care and cardiac surgery, preload management via fluid therapy relies on this mechanism. Limits of applicability: with excessive stretch (overstretch), contraction force decreases; the law does not account for the influence of afterload and neurohumoral regulation.

In practice

Understanding the mechanisms of heart failure and managing circulating blood volume in intensive care.

Fun fact

In a healthy heart, stroke volume can increase by 50% solely due to the Starling mechanism, without any hormones or nerve signals.

Concept graph →

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